The film starts with the ending of From Vegas to Macau II where the cardshark Ken's (Chow Yun Fat) lifelong lover-nemesis, Molly (Carina Lau), skydives without her parachute from her private jet. She now appears to be trapped inside some sort of laser bubble — unconscious, naked and horribly airbrushed — while her admirer, mad scientist Yik Tin Hang (Jacky Cheung) fumes about making Ken pay within his lair underneath Paradise Island, off the coast of Thailand. Over in Macau, Ken is busy having a meltdown over the wedding of the century of his daughter Rainbow (Kimmy Tong) to his godson Vincent (Shawn Yue). To help him snap out of it, his friend Mark (Nick Cheung) hypnotizes him into thinking Vincent is marrying his fat cousin. Things go very wrong when Michael (Andy Lau), the disciple of Ko Chun, phoned in with a warning to beware of Yik Tin Hang who has sent an explosive robot that looks like Michael to kill Ken. An explosion during the wedding causes both Rainbow and Vincent to fall into coma, while Ken and Mark are accused to have engulfed DOA's illicit money. Enraged, Ken swears to seek vengeance and to pursue the mastermind who has entangled them in his evil plans.